Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mouse models for evaluating candidate vaccines for outbreak pathogens.
| Disease | Mouse-adapted virus strain? | Knock-out mouse line | Age of mice | Paper/Review of model |
|---|---|---|---|---|
| Ebola | Yes | IFN-α/β R−/− or Stat1−/− | Neonates | 122 |
| Marburg | No | IFN-α/βR−/− | Neonates | |
| Lassa | No | STAT1−/− | 123 | |
| Nipah | No | IFN-αR−/− | Adults BALB/c and C57BL/6 intranasal inoculation (Dups 2014) | 124 |
| CCHF | No | STAT1−/− | 125 | |
| MERS | Yes | 43 | ||
| SARS | Yes | 44 | ||
| Zika | No | IFN-αR−/− | 126 | |
| Chikungunya | No | IFN-α/βR−/− | Neonates | 127 |
