. Author manuscript; available in PMC: 2017 Dec 6.

Published in final edited form as: Adv Exp Med Biol. 2017;1013:155–176. doi: 10.1007/978-1-4939-7299-9_6

Table 6.2.

Gamma-globin vectors

Name	Author and year	Main characteristics
d432β^Aγ	Persons 2003	- High variation depending on integration region and vector copy number
mLARβΔγV5 (V5)	Hanawa 2004	- Larger LCR reduced position effects and improved expression
G9	Samakoglu 2006	- Includes shRNA against sickle β-globin - Test only in vitro on MEL and HeLa cells stably expression sickle beta globin
V5m3	Pestina 2009	- 3′UTR of beta-globin corrected BERK SCA model
V5m3-400	Wilber 2011	- Added 400 bp core of cHS4 insulator
GGHI	Papanikolaou 2012	- No LCR elements, but instead contains a gamma-globin promoter with a −117 point mutation associated with HPFH, the HS40 enhancer from the alpha-globin locus, the HPFH-2 enhancer, and the cHS4 insulator - Only mild HbF production