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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Circ Res. 2017 Jul 10;121(6):662–676. doi: 10.1161/CIRCRESAHA.117.311519

Figure 7. Impact of UCP1 deficiency on atherosclerosis and glucose tolerance in comparison to Thermoneutrality.

Figure 7

A) Oil red O lipid staining of aortic sinus from the indicated mice following HFD treatment for 8 weeks at 22°C or 30°C housing, which quantification (right). B) Total body weight in mice after HFD. C) Ucp1−/− Ldlr−/− mice fed HFD for 12 weeks and were housed at 22°C or 30°C and assayed for plaque development. D) Glucose tolerance tests (GTT) were performed on 22°C or 30°C housed Ldlr−/− and Apoe−/− mice following 8 weeks HFD. E) Ucp1−/− Ldlr−/− and Ldlr−/− mice fed HFD for 8 weeks and housed at 22°C were assayed by GTT. F) Ucp1−/− Ldlr−/− mice fed HFD were housed at 22°C or 30°C and assayed for GTT. All data are representative experiments, containing n≥5 animals per group and repeated in two or three independent times. Statistical analysis was performed by unpaired student T-test, * p≤0.05, **p≤0.01, ***p≤0.001.