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. Author manuscript; available in PMC: 2019 Jan 2.
Published in final edited form as: AIDS. 2018 Jan 2;32(1):1–10. doi: 10.1097/QAD.0000000000001674

Figure 1. Long-term human engraftment of blood and spleen and sustained stable HIV-1 plasma antigenemia in TKO-BLT mice.

Figure 1

(A) Frequencies (top row) and numbers (bottom row) of human cell subsets determined by flow cytometric analysis of blood samples obtained from a representative uninfected TKO-BLT mice generated from a single human donor at 12 (n=35), 35 (n=32) and 45 (n=31) weeks post-transplant (wpt) or (B) spleen samples at 45wpt (n=15). (C) Plasma HIV-1 antigenemia in TKO-BLT mice as determined by p24 ELISA at 7, 12, 15, 18 and 22 weeks post infection (wpi). Splenic data is shown represent individual mice with horizontal bar at the median. Data points on longitudinal graphs denote mean values ±SEM at each time point. Statistical analyses were done by one way ANOVA with a Tukey multiple comparsions post test to compare all groups. Differences with a P value below 0.05 are shown. *P<0.05, **P<0.01***P<0.001, ****P<0.0001.