Table 2.
Results from the full cohort analysis and 500 replicates of random sampling and the D[100, 1400, 100] and D[275, 1050, 275] designs. We report average estimates and, in parentheses, average estimated standard errors on the log odds ratio (logistic) scale. ML = maximum likelihood, ACML = ascertainment–corrected maximum likelihood, WL = weighted likelihood, MI = multiple imputation.
| Variable | Full cohort | Random sampling | D[100,1400,100] | D[275,1050,275] | |||||
|---|---|---|---|---|---|---|---|---|---|
| ML | ML | MI | ACML | WL | MI | ACML | WL | MI | |
| Primary estimation targets | |||||||||
| SNP (βs) | −0.08 (0.07) | −0.09 (0.11) | −0.09 (0.11) | −0.15 (0.15) | −0.10 (0.20) | −0.14 (0.15) | −0.08 (0.12) | −0.08 (0.13) | −0.07 (0.12) |
| Smoking (within; βw) | 1.25 (0.20) | 1.25 (0.31) | 1.24 (0.28) | 1.18 (0.21) | 1.33 (0.30) | 1.27 (0.21) | 1.28 (0.25) | 1.28 (0.25) | 1.28 (0.23) |
| SNP by Smoking (within; βws) | −0.57 (0.22) | −0.57 (0.36) | −0.55 (0.34) | −0.54 (0.23) | −0.63 (0.33) | −0.59 (0.23) | −0.60 (0.28) | −0.59 (0.28) | −0.60 (0.27) |
| Time-varying covariates | |||||||||
| Study year (per 3 years) | 0.00 (0.01) | 0.00 (0.02) | 0.00 (0.01) | 0.00 (0.01) | 0.00 (0.01) | 0.00 (0.01) | 0.00 (0.01) | 0.00 (0.02) | 0.00 (0.01) |
| Time-fixed/baseline covariates | |||||||||
| Smoking (between; βb) | 2.05 (0.10) | 2.06 (0.15) | 2.05 (0.10) | 1.93 (0.21) | 2.09 (0.25) | 2.05 (0.10) | 2.01 (0.15) | 2.07 (0.17) | 2.05 (0.10) |
| Female | −0.15 (0.06) | −0.14 (0.10) | −0.15 (0.06) | −0.21 (0.15) | −0.14 (0.19) | −0.15 (0.06) | −0.17 (0.11) | −0.14 (0.12) | −0.15 (0.06) |
| Cigarettes/day (per 10 cigs/day) | 0.16 (0.02) | 0.16 (0.04) | 0.16 (0.02) | 0.08 (0.05) | 0.16 (0.07) | 0.16 (0.02) | 0.12 (0.04) | 0.16 (0.04) | 0.16 (0.02) |
| Pack years (per 10 pack years) | 0.11 (0.04) | 0.10 (0.06) | 0.11 (0.04) | 0.14 (0.08) | 0.12 (0.12) | 0.11 (0.04) | 0.13 (0.06) | 0.11 (0.08) | 0.11 (0.04) |
| Age (per 10 years) | 0.08 (0.05) | 0.08 (0.08) | 0.08 (0.05) | 0.05 (0.11) | 0.06 (0.15) | 0.08 (0.05) | 0.04 (0.08) | 0.08 (0.09) | 0.08 (0.05) |
| BMI (per 5 kg/m2) | 0.00 (0.04) | 0.00 (0.06) | 0.00 (0.04) | −0.05 (0.09) | −0.01 (0.12) | 0.00 (0.04) | −0.03 (0.07) | 0.00 (0.08) | 0.00 (0.04) |
| Response dependence model | |||||||||
| γ | 0.53 (0.10) | 0.53 (0.15) | 0.53 (0.10) | 0.54 (0.10) | 0.52 (0.10) | 0.53 (0.10) | 0.53 (0.11) | 0.52 (0.11) | 0.53 (0.10) |
| log(σ) | 0.82 (0.04) | 0.82 (0.06) | 0.82 (0.04) | 0.83 (0.07) | 0.80 (0.07) | 0.82 (0.04) | 0.82 (0.05) | 0.82 (0.05) | 0.82 (0.04) |