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. Author manuscript; available in PMC: 2018 Dec 5.
Published in final edited form as: Cell Metab. 2017 Oct 26;26(6):884–896.e5. doi: 10.1016/j.cmet.2017.09.024

Figure 4. Driving fusion does not increase lifespan.

Figure 4

(A) Mitochondrial networks in muscle cells of wild-type, drp-1 mutant, and wild-type worms overexpressing fzo-1 (sur-5p::fzo-1) on day 1. (B) Mitochondrial networks in intestinal cells from wild-type and drp-1 mutants on day 1. (C) Mitochondrial area:perimeter ratio showing that mitochondrial networks are more connected in drp-1 mutants. Mean ± SEM of 8 muscle cells and 10 intestinal cells from different worms. *p<0.05, ****p<0.0001 by t test. Driving fusion by deletion of drp-1 (D) or overexpressing fzo-1 (E) has no effect on lifespan. Lifespan extension by CA-AAK-2 (F) and DR (G) is suppressed in drp-1 mutants. RNAi knockdown of daf-2 (H) and cco-1 (I) extend lifespan in drp-1 mutants. See Table S1 for lifespan statistics.