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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Cancer Discov. 2017 Oct 12;7(12):1404–1419. doi: 10.1158/2159-8290.CD-17-0698

Figure 6. Endothelial activation and vascular disruption in CAR-T cell neurotoxicity.

Figure 6

A: Hematoxylin and eosin staining of medulla showing red blood cell extravasation into the surrounding parenchyma and Virchow-Robin space in the setting of minimal arteriolar wall disruption. B: Hematoxylin and eosin staining showing fibrinoid vessel wall necrosis and vascular occlusion. C: Perivascular CD8+ T cell infiltration. D: IHC for VWF showing VWF binding to capillaries. E: IHC for CD61 demonstrates intravascular microthrombi. F: IHC for CD31 showing reduplicated and disrupted endothelium. Size bars (100μm) are shown.