. Author manuscript; available in PMC: 2018 Apr 9.

Published in final edited form as: Bone Marrow Transplant. 2017 Oct 9;52(12):1629–1636. doi: 10.1038/bmt.2017.197

Table 3. Results of univariate and multivariate Cox regression analyses for association of patient and transplant factors with relapse-free and overall survival.

Characteristic		Univariate				Multivariate
		RFS		OS		RFS		OS
		HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Age, per 10 year		1.24 (1.01, 1.51)	0.04	1.30 (1.04, 1.62)	0.02	1.16 (0.89, 1.50)	0.27	1.17 (0.92, 1.48)	0.19
HCT-CI	0	1.0 (reference)	0.02	1.0 (reference	0.003	1.0 (reference)	0.02	1.0 (reference)	0.004
	1–2	0.85 (0.43,1.67)		1.06 (0.48,2.34)		0.83 (0.42,1.65)		1.05 (0.47, 2.33)
	≥ 3	1.77 (0.99,3.16)		2.51 (1.28,4.9)		1.78 (0.97,3.28)		2.53 (1.26, 5.08)
KPS	60–80	1.0 (reference)	0.42	1.0 (reference)	0.09
KPS	90–100	0.82 (0.52, 1.32)	0.42	0.65 (0.39, 1.07)	0.09
Donor type	MRD	1.0 (reference)	0.10	1.0 (reference)	0.06
	MUD	1.03 (0.57,1.85)		0.91 (0.47,1.74)
	MMRD	2.32 (0.8,6.69)		2.6 (0.89,7.57)
	MMUD	1.75 (1,3.06)		1.76 (0.97,3.19)
Conditioning regimen	TBI-based	1.0 (reference)	0.04	1.0 (reference)	0.07	1.0 (reference)	0.90
Conditioning regimen	Chemo-based	1.67 (1.01, 2.76)	0.04	1.65 (0.96, 2.83)	0.07	1.04 (0.55, 1.97)	0.90
CD34 selectionmethod	ISOLEX	1.0 (reference)	0.88	1.0 (reference)	0.61
CD34 selectionmethod	CliniMACS	1.04 (0.63, 1.71)	0.88	0.87 (0.50, 1.51)	0.61
Acute GVHD by 1 year	No	1.0 (reference)	0.002	1.0 (reference)	0.001
Acute GVHD by 1 year	Yes	2.17 (1.34,3.50)	0.002	2.32 (1.39,3.88)	0.001
Acute GVHD grade by 1 year	0–1	1.0 (reference)	<0.0001	1.0 (reference)	<0.0001	1.0 (reference)	<0.0001	1.0 (reference)	<0.0001
	2	1.97 (0.97,4.02)		2.62 (1.27, 5.39)		2.07 (1.01, 4.27)		2.90 (1.39, 6.04)
	3–4	5.43 (2.82,10.46)		5.61 (2.81, 11.22)		6.14 (3.12, 12.07)		6.14 (3.05, 12.36)
Chronic GVHD by 1 year	No	1.0 (reference)	0.62	1.0 (reference)	0.336
Chronic GVHD by 1 year	Yes	1.24 (0.54,2.85)	0.62	1.51 (0.65,3.51)	0.336