Table 4. Results of univariate Cox regression analysis for association of disease-specific factors with relapse-free and overall survival.
Characteristic | RFS | OS | |||
---|---|---|---|---|---|
| |||||
HR (95% CI) | p | HR (95% CI) | p | ||
| |||||
AML | |||||
| |||||
Disease status at HSCT | CR1 | 1.0 (reference) | 0.76 | 1.0 (reference) | 0.67 |
CR2 | 1.22 (0.66, 2.28) | 1.25 (0.63, 2.45) | |||
PR/refractory | 1.35 (0.41, 4.40) | 1.57 (0.48, 5.16) | |||
| |||||
Cytogenetic/ molecular risk | Favorable | 1.0 (reference) | 0.08 | 1.0 (reference) | 0.25 |
Intermediate | 5.16 (0.69, 38.37) | 4.78 (0.64, 35.65) | |||
Poor | 7.98 (105, 60.39) | 5.73 (0.74, 44.25) | |||
| |||||
Therapy-related AML | No Yes | 1.0 (reference) 1.87 (0.86, 4.07) | 0.12 | 1.0 (reference) 1.85 (0.80, 4.25) | 0.15 |
Yes | 1.87 (0.86, 4.07) | 1.85 (0.80, 4.25) | |||
| |||||
ALL | |||||
| |||||
Disease status at HSCT | CR1 | 1.0 (reference) | 0.01 | 1.0 (reference) | 0.06 |
Non-CR1 | 4.56 (1.41, 14.79) | 3.51 (0.94, 12.12) | |||
| |||||
Cytogenetic risk | Standard/good | 1.0 (reference) | 0.91 | 1.0 (reference) | 0.57 |
Poor | 1.07 (0.34, 3.37) | 1.50 (0.37, 6.01) | |||
| |||||
BCR-ABL positivity | No | 1.0 (reference) | 0.48 | 1.0 (reference) | 0.21 |
Yes | 1.64 (0.42, 6.35) | 3.92 (0.47, 32.63) | |||
| |||||
Elevated WBC count on diagnosis | No | 1.0 (reference) | 0.56 | 1.0 (reference) | 0.81 |
Yes | 0.65 (0.16, 2.73) | 0.80 (0.13, 4.80) | |||
| |||||
MDS | |||||
| |||||
Disease status at HSCT | CR | 1.0 (reference) | 0.22 | 1.0 (reference) | 0.30 |
Non-CR | 2.49 (0.58, 10.61) | 2.15 (0.50, 9.29) | |||
| |||||
Cytogenetic risk | Good | 1.0 (reference) | 0.11 | 1.0 (reference) | 0.21 |
Intermediate | 3.11 (0.97, 9.92) | 2.35 (0.71, 7.80) | |||
Poor/very poor | 3.32 (1.02, 10.8) | 2.88 (0.87, 9.58) | |||
| |||||
IPSS-R risk on diagnosis | Very low/low | 1.0 (reference) | 0.23 | 1.0 (reference) | 0.18 |
Intermediate | 1.01 (0.28, 3.57) | 1.06 (0.25, 4.45) | |||
High/very high | 2.09 (0.67, 6.5) | 2.46 (0.68, 8.81) | |||
| |||||
IPSS-R risk at HSCT | Very low/low | 1.0 (reference) | 0.06 | 1.0 (reference) | 0.09 |
Intermediate | 3.63 (1.26, 10.45) | 3.71 (1.14, 12.07) | |||
High/very high | 2.39 (0.73, 7.82) | 2.89 (0.81, 10.23) |