Skip to main content
. Author manuscript; available in PMC: 2018 Apr 9.
Published in final edited form as: Bone Marrow Transplant. 2017 Oct 9;52(12):1629–1636. doi: 10.1038/bmt.2017.197

Table 4. Results of univariate Cox regression analysis for association of disease-specific factors with relapse-free and overall survival.

Characteristic RFS OS

HR (95% CI) p HR (95% CI) p

AML

Disease status at HSCT CR1 1.0 (reference) 0.76 1.0 (reference) 0.67
CR2 1.22 (0.66, 2.28) 1.25 (0.63, 2.45)
PR/refractory 1.35 (0.41, 4.40) 1.57 (0.48, 5.16)

Cytogenetic/ molecular risk Favorable 1.0 (reference) 0.08 1.0 (reference) 0.25
Intermediate 5.16 (0.69, 38.37) 4.78 (0.64, 35.65)
Poor 7.98 (105, 60.39) 5.73 (0.74, 44.25)

Therapy-related AML No Yes 1.0 (reference) 1.87 (0.86, 4.07) 0.12 1.0 (reference) 1.85 (0.80, 4.25) 0.15
Yes 1.87 (0.86, 4.07) 1.85 (0.80, 4.25)

ALL

Disease status at HSCT CR1 1.0 (reference) 0.01 1.0 (reference) 0.06
Non-CR1 4.56 (1.41, 14.79) 3.51 (0.94, 12.12)

Cytogenetic risk Standard/good 1.0 (reference) 0.91 1.0 (reference) 0.57
Poor 1.07 (0.34, 3.37) 1.50 (0.37, 6.01)

BCR-ABL positivity No 1.0 (reference) 0.48 1.0 (reference) 0.21
Yes 1.64 (0.42, 6.35) 3.92 (0.47, 32.63)

Elevated WBC count on diagnosis No 1.0 (reference) 0.56 1.0 (reference) 0.81
Yes 0.65 (0.16, 2.73) 0.80 (0.13, 4.80)

MDS

Disease status at HSCT CR 1.0 (reference) 0.22 1.0 (reference) 0.30
Non-CR 2.49 (0.58, 10.61) 2.15 (0.50, 9.29)

Cytogenetic risk Good 1.0 (reference) 0.11 1.0 (reference) 0.21
Intermediate 3.11 (0.97, 9.92) 2.35 (0.71, 7.80)
Poor/very poor 3.32 (1.02, 10.8) 2.88 (0.87, 9.58)

IPSS-R risk on diagnosis Very low/low 1.0 (reference) 0.23 1.0 (reference) 0.18
Intermediate 1.01 (0.28, 3.57) 1.06 (0.25, 4.45)
High/very high 2.09 (0.67, 6.5) 2.46 (0.68, 8.81)

IPSS-R risk at HSCT Very low/low 1.0 (reference) 0.06 1.0 (reference) 0.09
Intermediate 3.63 (1.26, 10.45) 3.71 (1.14, 12.07)
High/very high 2.39 (0.73, 7.82) 2.89 (0.81, 10.23)