Table 1.
KAPPA cohort characteristics
Children with first year of life exposure data | Children with prenatal exposure data | |||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Characteristic | n (%) | Median first year of life | n (%) | Median prenatal | ||||
|
|
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PM2.5 (μg/m3) | NOX (ppb) | CO (ppm) | PM2.5 (μg/m3) | NOX (ppb) | CO (ppm) | |||
Cohort | 23,100 | 1.41 | 55.5 | 0.59 | 19,951 | 1.49 | 59.4 | 0.62 |
Sex | ||||||||
Female | 11,330 (49) | 1.42 | 55.6 | 0.59 | 9,748 (49) | 1.49 | 59.4 | 0.62 |
Male | 11,770 (51) | 1.41 | 55.5 | 0.59 | 10,203 (51) | 1.49 | 59.5 | 0.62 |
Race/Ethnicity | ||||||||
Black | 7,995 (35) | 1.32 | 50.8 | 0.54 | 7,220 (36) | 1.40 | 54.6 | 0.57 |
White | 9,034 (39) | 1.37 | 54.3 | 0.57 | 8,467 (42) | 1.45 | 58.0 | 0.60 |
Other a | 2,771 (12) | 1.69 | 65.6 | 0.70 | 2,643 (13) | 1.78 | 69.6 | 0.73 |
Unknown race | 3,300 (14) | 1.54 | 61.6 | 0.63 | 1,621 (8) | 1.70 | 69.7 | 0.69 |
Hispanic ethnicity | 1,839 (8) | 1.42 | 54.2 | 0.60 | 1,759 (9) | 1.51 | 58.7 | 0.63 |
Maternal education | ||||||||
<12th grade | 285 (1) | 1.50 | 59.9 | 0.63 | 280 (1) | 1.60 | 65.3 | 0.68 |
High school/GED | 2,605 (11) | 1.25 | 48.6 | 0.52 | 2,524 (13) | 1.32 | 52.3 | 0.54 |
Some college or more | 13,442 (58) | 1.42 | 55.9 | 0.59 | 13,113 (66) | 1.51 | 60.4 | 0.62 |
Missing | 6,768 (29) | 1.45 | 57.3 | 0.60 | 4,034 (20) | 1.56 | 61.1 | 0.64 |
Maternal asthma | ||||||||
Yes | 2,488 (11) | 1.39 | 54.4 | 0.58 | 2,419 (12) | 1.46 | 57.9 | 0.60 |
No | 17,998 (78) | 1.41 | 55.5 | 0.59 | 17,532 (88) | 1.50 | 59.6 | 0.62 |
Missing | 2,614 (11) | 1.44 | 57.3 | 0.60 | 0 | – | – | – |
Neighborhood Socioeconomic Status b | ||||||||
Highest SES | 14,401 (62) | 1.28 | 49.9 | 0.53 | 12,626 (63) | 1.36 | 53.6 | 0.56 |
Urban/Suburban | 2,293 (10) | 2.38 | 93.2 | 0.96 | 1,925 (10) | 2.53 | 100.4 | 1.01 |
Rural, average to low SES | 1,130 (5) | 0.95 | 37.7 | 0.40 | 974 (5) | 1.02 | 41.5 | 0.43 |
Lowest SES | 5,272 (23) | 1.65 | 64.2 | 0.68 | 4,423 (22) | 1.74 | 68.9 | 0.71 |
City Region | ||||||||
Metro Atlanta c | 2,425 (11) | 2.24 | 87.0 | 0.91 | 2,030 (10) | 2.35 | 92.0 | 0.95 |
≤16 km from metro Atlanta | 9,894 (43) | 1.57 | 62.0 | 0.64 | 8,449 (42) | 1.67 | 66.5 | 0.68 |
>16 km from metro Atlanta | 10,781 (47) | 1.14 | 45.0 | 0.49 | 9,472 (47) | 1.22 | 48.8 | 0.51 |
Kaiser Permanente enrollment duration d | ||||||||
Enrolled until age 2 | 17,960 (78) | 1.41 | 55.5 | 0.59 | 15,631 (78) | 1.49 | 59.6 | 0.62 |
Enrolled until age 3 | 14,251 (62) | 1.42 | 56.0 | 0.59 | 12,434 (62) | 1.50 | 60.4 | 0.62 |
Enrolled until age 4 | 10,999 (48) | 1.44 | 57.5 | 0.60 | 9,620 (48) | 1.54 | 62.3 | 0.63 |
Enrolled until age 5 | 8,592 (37) | 1.46 | 59.0 | 0.60 | 7,521 (38) | 1.57 | 64.5 | 0.64 |
Enrolled until age 6 | 6,629 (29) | 1.49 | 61.4 | 0.62 | 5,806 (29) | 1.59 | 66.7 | 0.65 |
Cumulative asthma incidence e | ||||||||
Age 2 | 1,994 (11) | 1.37 | 54.6 | 0.57 | 1,731 (11) | 1.45 | 58.6 | 0.60 |
Age 3 | 2,627 (18) | 1.39 | 55.0 | 0.58 | 2,316 (19) | 1.47 | 59.4 | 0.60 |
Age 4 | 2,650 (24) | 1.42 | 56.8 | 0.59 | 2,309 (24) | 1.51 | 61.4 | 0.61 |
Age 5 | 2,465 (29) | 1.47 | 58.9 | 0.60 | 2,132 (28) | 1.55 | 64.0 | 0.63 |
Age 6 | 2,149 (32) | 1.51 | 61.6 | 0.62 | 1,854 (32) | 1.59 | 67.1 | 0.66 |
SES indicates socioeconomic status, GED general educational development.
Includes Asian, American Indian, Alaska Native, Native Hawaiian or other Pacific Islander, and children identifying with more than one racial group
Neighborhood socioeconomic status was classified at census block group spatial resolution using child residence at time of birth and described using demographic clusters created by Georgia Department of Public Health32
Metro Atlanta defined as inside the I-285 perimeter of Atlanta
Reduction in sample size across follow-up reflects the shorter follow-up time available for children born in later years of the study (e.g., a child born in 2010 could be at most 3 years old at the time KAPPA follow-up ended in September 2013) as well as health maintenance organization enrollment attrition over time.
Cumulative asthma incidence (at least one asthma diagnosis (ICD-9 493.XX) and one asthma-related medication dispensing after the first year of life) calculated among children enrolled until each follow-up age