Table 2.
Nonparametric correlations between motor function and structural connectivity of a priori ROIs
Behavioral measures | |||||
---|---|---|---|---|---|
Structural connectivity of a priori ROIs | BBTAff (n = 42) | GripAff (n = 42) | Arm MIAff (n = 40) | Leg MIAff (n = 42) | Gait speed (n = 40) |
Ipsilesional Hemisphere | |||||
M1 ↔ PMC | 0.35 | 0.24 | 0.28 | 0.17 | 0.10 |
M1 ↔ SMA | 0.42* | 0.46* | 0.41 | 0.38 | 0.25 |
PMC ↔ SMA | 0.31 | 0.22 | 0.22 | 0.14 | −0.05 |
M1 ↔ CP | 0.74* | 0.67* | 0.67* | 0.63* | 0.55* |
PMC ↔ CP | 0.45* | 0.30 | 0.45* | 0.41 | 0.34 |
SMA ↔ CP | 0.66* | 0.56* | 0.63* | 0.63* | 0.54* |
M1 ↔ RN | 0.53* | 0.49* | 0.49* | 0.43* | 0.24 |
PMC ↔ RN | 0.35 | 0.28 | 0.35 | 0.34 | 0.23 |
SMA ↔ RN | 0.52* | 0.42* | 0.46* | 0.45* | 0.38 |
M1 ↔ Thalamus | 0.65* | 0.56* | 0.61* | 0.66* | 0.54* |
PMC ↔ Thalamus | 0.39 | 0.21 | 0.37 | 0.37 | 0.23 |
SMA ↔ Thalamus | 0.65* | 0.57* | 0.63* | 0.64* | 0.46* |
Basal Ganglia & Cerebellum | |||||
Caudate ↔ Thalamus | 0.05 | −0.07 | 0.10 | 0.10 | −0.09 |
Putamen ↔ Thalamus | 0.37 | 0.36 | 0.27 | 0.40 | 0.43* |
GP ↔ Thalamus | 0.23 | 0.29 | 0.25 | 0.33 | 0.36 |
Cerebellum ↔ Thalamus | 0.50* | 0.51* | 0.43* | 0.48* | 0.39 |
Interhemispheric Connectivity | |||||
M1 ↔ M1 | 0.46* | 0.30 | 0.31 | 0.30 | 0.14 |
PMC ↔ PMC | 0.24 | 0.01 | 0.16 | 0.08 | 0.06 |
SMA ↔ SMA | 0.35 | 0.14 | 0.22 | 0.21 | 0.23 |
Values in the table are Spearman's coefficients (r).
Abbreviations: ROIs, regions of interest; BBTAff, Box and Block Test (affected extremity); GripAff, grip strength (affected extremity); Arm MIAff, Arm Motricity Index score (affected extremity); Leg MIAff, Leg Motricity Index score (affected extremity); M1, primary motor cortex; PMC, premotor cortex; SMA, supplementary motor area; CP, cerebral peduncle; RN, red nucleus; GP, globus pallidus.
*Significant at corrected P ≤ 0.003.