Figure 5.

Schematic representation of the network changes identified in analysis. A, The limbic or affective striato‐pallido‐thalamo‐cortical loop. Arrows represent anatomical connections as described in Alexander et al. [1986]. The loop consists of the ventral striatum (green), the globus pallidus (magenta), the thalamus (yellow), and limbic cortical structures such as the orbitofrontal cortex and anterior cingulate gyrus (red). We propose that this structural and functional network is involved in incentive valuation and reward‐driven behavioral modification. B, Increased functional connectivity correlates of ICB. Bands indicate select regions of significantly increased connectivity, generally corresponding to the cortico‐striatal‐pallido‐thalamo‐cortical loop, which is highly connective in ICB+ PD individuals. Dashed connecting line between ventral striatum and subgenual ACC represents functional connectivity related to reward‐incentivized learning.