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. 2017 Dec 6;7:17039. doi: 10.1038/s41598-017-17202-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Boxplots of metabolite concentrations in plasma samples from newborns included in the HYPOTOP trial. Note: acetoacetate, succinate, malate and α-ketoglutarate detected in 77, 95, 92 and 60% and other analytes in 100% of samples, concentrations < LLOQ were set to 1/2xLLOQ; p-values calculated employing the two-tailed Wilcoxon rank sum test for equal medians.