Table 4.

Main descriptors of the distribution of concentrations (µmol L⁻¹) in plasma samples collected from the control group (N = 19) and newborns enrolled in the HYPOTOP trial 48 h after the administration of the first dose of TPM. Note: p-value calculated employing the two-tailed Wilcoxon rank sum test for equal medians (α = 0.05).

Metabolite	Control Group				HYPOTOP (48 h)				p-value
	Range P10-P90	Median	Mean ± s	>LLOQ (%)	Range P10-P90	Median	Mean ± s	>LLOQ (%)
Pyruvate	6–50	11	100 ± 200	100	12–200	40	100 ± 200	100	1.6 × 10−5
Lactate	300–1000	700	700 ± 400	100	500–3000	1000	1600 ± 2000	100	0.002
Acetoacetate	20–700	100	300 ± 300	100	0.7–30	7	35 ± 130	82	1.7 × 10−8
β-Hydroxybutyrate	13–700	150	300 ± 300	100	4–15	8	9 ± 5	100	4.9 × 10−8
Succinate	0.13–0.7	0.3	0.4 ± 0.3	95	0.11–0.8	0.5	0.4 ± 0.2	100	0.235
Fumarate	0.5–1.1	0.7	0.7 ± 0.2	79	0.3–1.3	0.6	0.8 ± 0.8	100	0.234
Malate	1.0–8	1.2	3 ± 4	100	0.7–5	2	3 ± 4	92	0.535
α-Ketoglutarate	0.5–2	1.2	1.3 ± 0.6	74	0.02–7	1.2	2 ± 4	81	0.672