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. 2017 Dec 6;7:17034. doi: 10.1038/s41598-017-17313-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The tau immunogen Tau379–408[P-Ser396, 404] elicits a robust and sustained antibody response. (A–C) IgG response towards the immunogen was strong and long-lasting, and comparable in males vs. females. It was strong at T1 (1 week after the 3^rd immunization), peaked at T2 (2 months after the 4^th and last immunization) and remained strong thereafter (T3-Tf: 5, 8, 11, and 16 months after the 4^th immunization). Higher IgG levels were detected in wt mice compared to 3xTg mice. (D–F) IgM response was not as strong as the IgG response but showed a similar pattern as the IgG response except that the IgM response was comparable in the wt vs. the 3xTg mice. (G,H) Plasma (1:100) obtained from a high titer mouse at the end of the study (Tf) stained tau aggregates in a control 3xTg mouse, whereas plasma from a low titer control mouse did not. Scale bar: 125 μm.