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. 2017 Dec 6;7:17034. doi: 10.1038/s41598-017-17313-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tau immunization reduces microgliosis in 3xTg mice to wt levels. (A–C) Semi-quantitative analysis of Iba1 immunoreactivity in the subiculum revealed that 3xTg mice had more microgliosis than wt mice (males and females: p = 0.0013; males: p = 0.0286; females: p = 0.0310), and the tau immunotherapy reduced microgliosis in 3xTg mice to wt levels (males and females: p = 0.0056; males: p = 0.0699; females: p = 0.0294). ^#p < 0.05; ^##p < 0.01 compared to wt control. *p < 0.05; **p < 0.01 compared to 3xTg control. See text for exact p-values.