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. 2017 Dec 6;7:17034. doi: 10.1038/s41598-017-17313-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tau immunization prevents phospho-tau histopathology. (A–D) PHF1 immunostaining revealed extensive tau pathology in the hippocampus (A: 5X objective, B: 20X objective) of 3xTg mice, that was greatly reduced in immunized mice (C,D). (E–H) Only background staining was seen in the wt mice. (I–K) Quantitative analysis of the PHF1 staining revealed significant reduction in tau aggregates in the combined group (I: 74%, p = 0.0008) as well as in males (J: 68%, p = 0.0437) and females (K: 78%, p = 0.0120) analyzed separately. Scale bar: 250 μm (A), 125 µm (B). *p < 0.05; ***p < 0.001 compared to 3xTg control. See text for exact p-values.