Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 6;7:17034. doi: 10.1038/s41598-017-17313-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Tau immunization diminishes Aβ burden. (A–D) Aβ immunostaining revealed extensive Aβ plaque burden in subiculum region of the hippocampus (A: 5X objective, B: 20X objective) of 3xTg mice, that was greatly reduced in immunized mice (C,D). (E–H) Only background staining was seen in the wt mice. (I–K) Quantitative analysis of the Aβ staining revealed significant reduction in Aβ plaque burden in the combined group (I: 84%, p < 0.0001) as well as in males (J: 61%, p = 0.0033) and females (K: 97%, p = 0.0001) analyzed separately. Scale bar: 250 μm (A), 125 µm (B). **p < 0.01; ****p < 0.0001 compared to 3xTg control. See text for exact p-values.