Table 1.
General characteristics of the study subjects and of the rare CNVs in the T2D and control groups.
| Characteristic | T2D group | Control group | P value |
|---|---|---|---|
| N | 686 | 194 | |
| General characteristics | |||
| Male/female sex | 205/481 | 89/105 | <0.001* |
| Age, years | 49 ± 12 | 50 ± 7 | 0.086 |
| BMI, kg/m2 | 29.2 ± 6.4 | 27.4 ± 4.3 | <0.001* |
| Total cholesterol, mg/dL | 210.5 ± 57 | 205.5 ± 50 | 0.119 |
| Triglycerides, mg/dL | 197.5 ± 133 | 133 ± 63 | <0.001* |
| MDS1 ancestry vector | −0.0047 ± 0.0291 | 0.0072 ± 0.0355 | <0.001* |
| MDS2 ancestry vector | 0.0018 ± 0.0067 | 0.0018 ± 0.0072 | 0.653 |
| MDS3 ancestry vector | 0.0009 ± 0.0055 | 0.0001 ± 0.0061 | 0.094 |
| Rare CNVs | |||
| Number of Rare CNVs | 526 | 131 | |
| Deletions | 189 (35.9) | 37 (28.2) | |
| Duplications | 337 (64.1) | 94 (71.8) | 0.097 |
| CNVs size in Mb | 214.5 ± 230.3 | 208.2 ± 245.9 | 0.759 |
| Deletions | 171.3 ± 164.8 | 156.6 ± 87.4 | 0.335 |
| Duplications | 241.3 ± 255 | 254.1 ± 354.1 | 0.543 |
| Genic Rare CNVs | |||
| Number of Genic Rare CNVs | 358 | 83 | |
| Deletions | 86 (24) | 17 (20.5) | |
| Duplications | 272 (76) | 66 (79.5) | 0.492 |
| CNVs size in Mb | 233.7 ± 245.3 | 257.7 ± 351.1 | 0.282 |
| Deletions | 181.7 ± 219.2 | 160.5 ± 78 | 0.552 |
| Duplications | 246.1 ± 244.6 | 311.6 ± 354.9 | 0.119 |
Data presented as counts (percentage) or median ± interquartile range.
P value between T2D and control groups by X2 and Mann–Whitney U test (numerical variables were not normally distributed).
T2D: type 2 diabetes; MDS1: Multidimensional scaling; BMI: Body Mass Index (kg/m2) CNVs: Copy number variations. *P < 0.05.