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. 2017 Dec 6;7:17071. doi: 10.1038/s41598-017-16897-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detail of filamentous actin associated with intrascleral channels. (a–e) 2-photon serial optical sections through a collector channel (CC) show filamentous actin (F-actin; red) association with the wall of a CC (signal void in collagen second harmonic generation (SHG; cyan)). (e) CC ostium in the outer wall of Schlemm’s canal (OWSC; SC). (f,g) F-actin signal was relatively intense in the trabecular meshwork (TM)/inner wall of SC (IWSC) region. Orthogonal reconstruction showed CC ostium (dotted line) association with a classic right-angled CC (~17 μm diameter) connecting to an intrascleral plexus (ISP). (g) 3X magnification of the ostium shown in f. (h–j) 3D reconstruction from isosurface maps showed ISP association with CCs (yellow; from solid-modeling of SHG signal voids) within the sclera (cyan; h). Scleral collagen SHG was rendered transparent (h) to reveal associations in 3D tissue space. TM reconstruction (red) revealed a latticed mesh-like structure (h–j). z: tissue depth relative to the outer scleral surface.