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. 2017 Dec 6;7:17063. doi: 10.1038/s41598-017-16624-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Amphioxus PIAS inhibits NF-κB activation induced by different signals. (a–f) Luciferase reporter assays show that bPIAS can repress NF-κB activation mediated by the cytokines TNFα and several NF-κB related signal transducers of amphioxus in HEK293T cells. All reporter assays were performed in triplicate and repeated at least twice. Values are expressed as the mean ± SD; *P < 0.05, **P < 0.01, ***P < 0.001.