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. 2017 Dec 6;7:17047. doi: 10.1038/s41598-017-17270-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vitamin K2 rescues hematopoietic system in Drosophila third instar larvae with lymphoma induced by heix mutation. (A) Images (X40) circulating hemocytes labeled by Giemsa staining kit from larvaes in heix ^k11403 /heix ¹ on control medium, in control (Canton S) on control medium, and in heix ^k11403 /heix ¹ on VK2 supplemented medium. Images reveal an increase number of crystal cells, (black arrows). Total circulating hemocytes counted from at least twenty third instar larvaes of each genotype. The proportion of crystal cell observed in total circulating hemocytes. (B) Images (X20) lymph glands in third instar larvaes in heix ^k11403 /heix ¹ on control medium, in control (Canton S) on control medium and in heix ^k11403 /heix ¹ on VK2 supplemented medium. They show a significant increase size of mutant lymph glands indicating hyperplasia which responded to treatment with VK2. Percentage of lobulation in lymph gland reduced significantly. (C) Images (X20) brain in third instar larvae in heix ^k11403 /heix ¹ on control medium, in control (Canton S) on control medium and in heix ^k11403 /heix ¹ on VK2 supplemented medium. They show a significant hypertrophy in mutant brains which responded to treatment with VK2. Control media contain 50 mM Ethanol (EtOH) and treatment media contain 50 mM VK2. Means normalized to control (Canton S). Error bars indicate SEM. Analysis of variance (ANOVA/Dunnett: *P < 0.05, **P < 0.01, ***P < 0.001).