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. 2017 Dec 6;7:17047. doi: 10.1038/s41598-017-17270-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Prevention of lymphoma was vitamin K2 dependent. Testing the ability of VK2 to reduce recurrence of lymphoma. Follow-up of second-generation flies fed on VK2, divided into two groups: one group continuously reared on VK2 medium and the other on ordinary control medium. (A) Reappearance of black spots after stopping VK2 treatment. The percentage of larvae with recurrent spots very high. (B) Pupal pip out rate of adult flies decreased after stopping VK2 treatment. (C) ROS expression clearly increased after stopping VK2 treatment, recurrence of ROS release was significant. DAPI stain (blue) and ROS staining (CM-H2DCFDA) (green). (D) Inhibition of ATP production after stopping VK2 treatment, decrease in ATP production was significant. DAPI stain (blue) and anti-ATP antibodies (ATP5A). Control media contain 50 mM Ethanol (EtOH) and treatment media contain 50 mM VK2. Means normalized to control (Canton S). Error bars indicate SEM. Analysis of variance (ANOVA/Dunnett: *P < 0.05, **P < 0.01, ***P < 0.001).