Table 1.
Genome-wide significant loci identified in a GWAS meta-analysis of n = 15,997 participants of Hispanic/Latino ancestry from four studies, that were previously reported.
| Locus | Lead SNP | Chr | Position (hg19) | A1 | A2 | CAF | β (ms) | Direction of β | SE (ms) | P-val | Phet |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RNF207 | rs7531322 | 1 | 6,299,823 | C | G | 0.30 | 1.73 | ++++ | 0.24 | 1.04e–12 | 0.17 |
| NOS1AP | rs12143842 | 1 | 162,033,890 | T | C | 0.22 | 3.46 | ++++ | 0.25 | 3.30e–42 | 0.35 |
| ATP1B1 | rs12035622 | 1 | 169,102,340 | A | T | 0.19 | −2.36 | −−−− | 0.27 | 8.77e–18 | 0.73 |
| SLC8A1 | rs35450971 | 2 | 40,754,314 | T | C | 0.79 | 1.71 | ++++ | 0.26 | 8.37e–11 | 0.45 |
| TTN | rs55863869 | 2 | 179,647,546 | A | G | 0.84 | −1.92 | −−−− | 0.30 | 2.40e–10 | 0.42 |
| SCN5A | rs3922844 | 3 | 38,624,253 | T | C | 0.37 | 1.77 | ++++ | 0.22 | 9.52e–16 | 0.06 |
| SLC35F1 | rs2078383 | 6 | 118,706,643 | T | C | 0.25 | 1.83 | ++++ | 0.25 | 2.07e–13 | 0.82 |
| KCNH2 | rs35760656 | 7 | 150,658,678 | A | G | 0.35 | 1.70 | ++++ | 0.23 | 4.21e–13 | 0.50 |
| KCNQ1 | rs12271931 | 11 | 2,478,519 | A | G | 0.93 | 3.92 | ??++ | 0.57 | 4.07e–12 | 0.13 |
| LITAF | rs735951 | 16 | 11,693,536 | A | G | 0.41 | −1.55 | −−−− | 0.22 | 5.92e–13 | 0.78 |
| SETD6 | rs185639574 | 16 | 58,550,052 | T | G | 0.34 | −2.53 | −−−− | 0.24 | 6.67e–27 | 0.52 |
| PRKCA | rs56152251 | 17 | 64,280,153 | A | G | 0.44 | −1.60 | −−−− | 0.21 | 6.64e–14 | 0.85 |
| KCNE1 | rs12626657 | 21 | 35,828,173 | A | G | 0.15 | 2.69 | +++− | 0.31 | 1.14e–17 | 0.01 |
Chr: chromosome number. Position: base pair position in Build 37 (hg19). A1, A2: coded/non-coded alleles. β: effect estimate in ms. Direction of β: direction of the effect estimates per study following this order: WHI, MESA, HCHS/SOL and Starr County; ‘?’ means the SNP is not present in that particular study. SE: standard error. Phet: P-val for Cochran’s Q test of homogeneity among cohorts.