Table 2.
Genome-wide significant secondary SNPs from previously reported regions, identified in meta-analyzed conditional analysis.
| Locus | SNP | Chr | Position (hg19) | A1 | A2 | CAF | β (ms) | Direction of β | SE (ms) | P-val | PHet |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NOS1AP | rs3934467 | 1 | 162,182,677 | T | C | 0.28 | 1.62 | ++++ | 0.24 | 2.26e–11 | 0.78 |
| rs73017364 | 1 | 162,184,746 | T | C | 0.87 | 1.73 | ++++ | 0.31 | 3.74e–08 | 0.65 | |
| ATP1B1 | rs1320977 | 1 | 169,073,388 | A | G | 0.15 | −2.30 | −−−+ | 0.29 | 2.61e–15 | 0.02 |
| rs1138486 | 1 | 169,101,935 | T | C | 0.14 | −2.46 | −−−? | 0.31 | 6.98e–15 | 0.55 | |
| SCN5A | rs6762565 | 3 | 38,582,191 | T | C | 0.19 | −1.65 | ?−−? | 0.29 | 1.94e–08 | 0.19 |
| KCNQ1 | rs78695585 | 11 | 2,644,544 | A | G | 0.04 | 3.48 | ++++ | 0.59 | 2.82e–09 | 0.63 |
Chr: chromosome number. Position: the base pair position in Build 37 (hg19). A1, A2: coded/non-coded alleles. CAF: coded allele frequency. β: effect estimate in ms for the highest associated SNP upon conditional analysis. Direction: the direction of the effect estimates; order is WHI, MESA, HCHS/SOL, and Starr County; ‘?’ means the SNP was not present for a particular study. SE: standard error (ms). Phet: P-val for Cochran’s Q test of homogeneity among cohorts, for the highest associated SNP upon conditional analysis.