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. 2017 Dec 6;7:17056. doi: 10.1038/s41598-017-17316-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The PF14 analogue C22-PF14-O provides efficient and safe gene delivery in vivo. (a) Systemic in vivo gene delivery efficacies of CPP/pDNA at N/P4, 20 μg pDNA dose. (b) The effect of increasing the pDNA dose on in vivo gene induction at N/P2 and pDNA 50 μg. Statistical analysis is presented in the Supplementary Data.