Table 1.
The peptide sequences used in the current study.
| Name | PF iteration | Sequence | Modifications/Properties |
|---|---|---|---|
| PF14 | CH3(CH2)16-CONH-AGYLLGKLLOOLAAAALOOLL-NH2 | Net charge +5 | |
| PF6 | CH3(CH2)16-CONH-AGYLLGK(a)INLKALAALAKKILL-NH2 | Net charge +10(a) | |
| PF14 net charge modifications | |||
| PF14-O | PF1450 | CH3(CH2)16-CONH-AGYLLGKLLOOLAOOALOOLL-NH2 | A14 −>O, A15 −>O Net charge +7 |
| PF14-E | PF1451 | CH3(CH2)16-CONH-AGYLLGKLLEOLAAAALOOLL-NH2 | O10 −>E Net charge +3 |
| PF14 fatty acid chain modifications | |||
| C0-PF14 | PF150 | NH2-AGYLLGKLLOOLAAAALOOLL-NH2 | No fatty acid Net charge +6 |
| C10-PF14 | PF155 | CH3(CH2)8-CONH-AGYLLGKLLOOLAAAALOOLL-NH2 | Carbon tail length 10 Net charge +5 |
| C22-PF14 | PF161 | CH3(CH2)20-CONH-AGYLLGKLLOOLAAAALOOLL-NH2 | Carbon tail length 22 Net charge +5 |
| PF14 net charge and fatty acid chain modifications | |||
| C22-PF14-O | PF1452 | CH3(CH2)20-CONH-AGYLLGKLLOOLAOOALOOLL-NH2 | A14 −>O, A15 −>O Carbon tail length 22 Net charge +7 |
(a)Four trifluoromethylquinoline moieties attached to succinylated lysine tree; overall calculated charge of the peptide is +10 at pH 7.4. O=ornithine.