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. 2017 Nov 8;43(1):52–79. doi: 10.1038/npp.2017.204

Table 2. Antinociceptive Effects of Cannabinoids in Pre-Clinical Models of Acute Inflammatory Pain.

Pain model Type Treatment Route Species Mechanical Thermal Weight bearing Mechanism of action Edema Edema receptor Citation
Carrageenan Agonist THC p.o. Rat N/A N/A N/A N/A Decrease N/A Sofia et al, 1973
    HU210 i.p. Rat N/A N/A yes CB1 Decrease CB1 & CB2 Clayton et al, 2002; Elmes et al, 2005
  Phytocannabinoid THCV i.p. Mouse N/A Plantar N/A Non-CB Decrease CB2 Bolognini et al, 2010
  CB1 agonist ACEA i.pl. Rat von Frey Plantar N/A CB1 N/A N/A Gutierrez et al, 2007
  CB1 PAM ZCZ011 i.p. Mouse von Frey N/A N/A CB1 No Δ N/A Ignatowska-Jankowska et al, 2015c
  CB2 agonist GW405833 i.p. Rat N/A N/A yes CB2 Decrease CB2 Clayton et al, 2002
    JWH133 i.p. Rat N/A N/A yes CB2 Decrease CB2 Elmes et al, 2005
    AM1241 i.p. Rat N/A Plantar N/A CB2 No Δ N/A Bingham et al, 2007; Nackley et al, 2003; Quartilho et al, 2003
    AM1241 i.pl. Rat von Frey Plantar N/A CB2 N/A N/A Quartilho et al, 2003 (plantar only); Gutierrez et al, 2007; Nackley et al, 2003 (von Frey and plantar)
  CB2 inverse agonist JTE-907   Mouse N/A N/A N/A N/A Decrease N/A Iwamura et al, 2001
  CB2 agonist + CB1 agonist AM1241 + ACEA i.pl. Rat N/A Plantar N/A N/A Decrease CB2 Gutierrez et al, 2007
  FAAH inhibition FAAH KO N/A Mouse N/A Plantar N/A CB2 Decrease CB2 Lichtman et al, 2004; Wise et al, 2008
    URB597 i.p. Mouse N/A No N/A N/A Decrease CB2 Holt et al, 2005 (edema only); Costa et al, 2010
    URB597 i.pl. Rat N/A N/A yes PPAR-α No Δ N/A Jhaveri et al, 2008
    URB937 i.p. Mouse von Frey & pressure Plantar N/A CB1 Decrease CB1 & CB2 Clapper et al, 2010
    JNJ-1661010   Rat N/A Plantar N/A N/A N/A N/A Karbarz et al, 2009
    PF-3845 i.p. Mouse von Frey N/A N/A N/A Decrease N/A Ghosh et al, 2013
  MAGL inhibition URB602 i.p. Mouse N/A Plantar N/A CB2 Decrease CB2 Comelli et al, 2007
    JZL184 i.p. Mouse von Frey N/A N/A CB1 & CB2 Decrease CB2 Ghosh et al, 2013
    KML129 i.p. Mouse von Frey N/A N/A CB1 & CB2 Decrease CB2 Ignatowska-Jankowska et al, 2014
  FABP SBFI26 i.p. Mouse N/A Plantar N/A N/A Decrease N/A Kaczocha et al, 2014
    SBFI50 i.p. Mouse N/A Plantar N/A N/A Decrease N/A Kaczocha et al, 2014
    FABP5/7 KO N/A Mouse N/A Plantar N/A PPAR-α & TRPV1 Decrease N/A Kaczocha et al, 2015
  FAAH inhibition + NSAID URB937 + Indomethacin p.o. Mouse Pressure Plantar N/A N/A Decrease N/A Sasso et al, 2012
    PF-3845 + Diclofenac i.p. Mouse von Frey N/A N/A CB1 & CB2 N/A N/A Grim et al, 2014
  FAAH & MAGL inhibition PF-3845 + JZL184 i.p. Mouse von Frey N/A N/A CB1 & CB2 Decrease CB2 Ghosh et al, 2015
    SA-57 i.p. Mouse von Frey N/A N/A CB1 & CB2 Decrease CB2 Wilkerson et al, 2017
  FAAH inhibition + TRPV1 antagonism AA-5-HT i.p. Mouse Randall-Stiletto Plantar N/A CB1 & TRPV1 Decrease TRPV1 Costa et al, 2010
  FAAH inhibition + TRPV1 antagonism AA-5-HT i.pl. Mouse no No N/A N/A N/A N/A Costa et al, 2010
  FAAH & sHE inhibition URB937 + TPPU p.o. Mouse pressure Plantar N/A N/A Decrease N/A Sasso et al, 2015
LPS (high dose) Agonist WIN55212-2 i.p. Mouse N/A HP N/A N/A Decrease N/A Naidu et al, 2010
    CP55,940 i.p. Mouse N/A HP N/A CB1 & CB2 Decrease CB2 Kinsey et al, 2011a
  CB2 agonist O-3223 i.p. Mouse N/A HP N/A CB2 Decrease CB2 Kinsey et al, 2011a
LPS (high dose) FAAH inhibition FAAH KO N/A Mouse N/A HP N/A CB1 Decrease CB2 Naidu et al, 2010
    URB597 i.p. Mouse N/A HP N/A CB1 Decrease CB2 Naidu et al, 2010
LPS (low dose) FAAH inhibition FAAH KO N/A Mouse von Frey N/A N/A CB1 & CB2 N/A N/A Booker et al, 2012
    URB597 i.p. Mouse von Frey N/A N/A N/A N/A N/A Booker et al, 2012
    OL-135 i.p. Mouse von Frey N/A N/A N/A N/A N/A Booker et al, 2012
    PF-3845 i.p. Mouse von Frey N/A N/A CB1 & CB2 N/A N/A Booker et al, 2012
    PF-3845 i.pl. Mouse von Frey N/A N/A N/A N/A N/A Booker et al, 2012
  DAGL-β inhibition DAGL-β KO N/A Mouse von Frey N/A N/A N/A N/A N/A Wilkerson et al, 2016a
    KT-109 i.p. Mouse von Frey N/A N/A Non-CB N/A N/A Wilkerson et al, 2016a
    KT-109 i.pl. Mouse von Frey N/A N/A N/A N/A N/A Wilkerson et al, 2016a
  ABHD6 inhibition KT-195 i.p. Mouse von Frey N/A N/A N/A N/A N/A Wilkerson et al, 2016a
  Agonist THC i.p. Mouse von Frey N/A N/A N/A N/A N/A Booker et al, 2012

Abbreviations: HP, hot plate; i.p., intraperitoneal; i.pl., intraplantar; N/A, not assessed; non-CB, not blocked by CB1 or CB2 receptors; p.o., given via gavage.