Table 5. Antinociceptive Effects of Cannabinoids in Preclinical Models of Neuropathic Pain.

			Anti-allodynic/Anti-hyperalgesic Stimulus Modality			Receptor Involvement (Yes/No)
Target	Drug	Species	Mechanical	Thermal/Heat	Cold	CB1	CB2	Reference(s)
Spinal nerve ligation
CB1 & CB2	CP55,940	Mouse, rat	+			Y/N	Y/N	Sain et al, 2009; Scott et al, 2004
	WIN	Rat	+	+	+	Y	N	Bridges et al, 2001; LaBuda and Little, 2005; Leichsenring et al, 2009; Yu et al, 2010
CB2	AM1241	Mouse	+	+		N	Y	Beltramo et al, 2006; Hsieh et al, 2011; Ibrahim et al, 2003
	GW405833	Rat	+					Leichsenring et al, 2009
FAAH	URB597	Rat	+					de Novellis et al, 2011
Partial sciatic nerve ligation (pSNL)
CB1 & CB2	AEA	Mouse, rat	+	+		Y	N	Desroches et al, 2014b; Helyes et al, 2003
	CP55,940	Rat	+					Fox et al, 2001
	HU-210	Rat	+			Y	Y	Fox et al, 2001; Jayamanne et al, 2006; Mitchell et al, 2005; Vuong et al, 2008
	WIN	Mouse, rat	+	+	+	Y/N	Y/N	Desroches et al, 2014b; Fox et al, 2001; Guindon et al, 2007; Gunduz et al, 2011; Lever et al, 2007
CB2	GW405833	Mouse, rat	+			Y	N	Li et al, 2017; Valenzano et al, 2005; Whiteside et al, 2005
	JWH133	Mouse	+				Y	Klauke et al, 2014; Yamamoto et al, 2008
FAAH	URB597	Mouse, rat	+	+		Y	N	Desroches et al, 2008, 2014b
PPARα	PEA	Rat	+				Y	Helyes et al, 2003
Chronic constriction injury (CCI)
CB1 & CB2	AEA	Rat	+	+	+	Y		Starowicz et al, 2012
	CP55,940	Mouse, rat	+	+		Y	N	Kinsey et al, 2011a; De Vry et al, 2004
	WIN	Mouse, rat	+	+	+	Y	Y/N	Adamson Barnes et al, 2016; Brownjohn and Ashton, 2012; Costa et al, 2004; Hama and Urban, 2004; Herzberg et al, 1997; Kazantzis et al, 2016; Lim et al, 2003; Linsell et al, 2015; Liu and Walker, 2006; Pascual et al, 2005; La Rana et al, 2008
	THC	Mouse, rat	+	+	+	Y		Kinsey et al, 2013; Mao et al, 2000; De Vry et al, 2004; Xie et al, 2016
CB2	AM1241	Rat	+					Wilkerson et al, 2012b
	AM1710	Rat	+					Wilkerson et al, 2012a
	GW405833	Rat	+					Brownjohn and Ashton, 2012; Hu et al, 2009
	JWH-015	Mouse	+	+	+		Y	Hervera et al, 2010
FAAH	PF-3845	Mouse, rat	+		+	Y	Y	Ghosh et al, 2015; Grim et al, 2014; Kinsey et al, 2010; Malek et al, 2016; Schlosburg et al, 2010
	URB597	Mouse, rat	+	+	+	Y/N	Y/N	Adamson Barnes et al, 2016; Caprioli et al, 2012; Kinsey et al, 2009; Russo et al, 2007; Starowicz et al, 2012, 2013; Toniolo et al, 2014
	URB937	Mouse	+	+		Y	N	Clapper et al, 2010; Sasso et al, 2012
MAGL	JZL184	Mouse, rat	+	+	+	Y	Y/N	Adamson Barnes et al, 2016; Crowe et al, 2015; Ghosh et al, 2015; Ignatowska-Jankowska et al, 2015a; Kinsey et al, 2009, 2010, 2013; Schlosburg et al, 2010; Toniolo et al, 2014
	MJN110	Mouse	+	+		Y	Y/N	Ignatowska-Jankowska et al, 2015a; Wilkerson et al, 2016b
Dual FAAH & MAGL	JZL195	Mouse	+		+			Adamson Barnes et al, 2016
	SA-57	Mouse	+	+				Wilkerson et al, 2017
DAGLβ	KT-109	Mouse	+	+				Wilkerson et al, 2016a
PPARα	PEA	Mouse	+	+		Y	N	Di Cesare Mannelli et al, 2013; Costa et al, 2008
Cisplatin-induced peripheral neuropathy
CB1 & CB2	AEA	Mouse	+			Y	N	Khasabova et al, 2012
	THC	Mouse	+					Harris et al, 2016
	WIN	Rat	+			Y	Y/N	Vera et al, 2013
CB2	AM1710	Rat	+		+	N	Y	Deng et al, 2012
	JWH133	Rat	+				Y	Vera et al, 2013
FAAH	URB597	Mouse, rat	+		+	Y	Y/N	Guindon et al, 2013; Khasabova et al, 2012
	URB937	Rat	+		+	Y	Y	Guindon et al, 2013
MAGL	JZL184	Mouse, rat	+		+	Y	Y/N	Guindon et al, 2013; Khasabova et al, 2014
Paclitaxel-induced peripheral neuropathy
CB1 & CB2	CP55,940	Mouse	+		+	Y	Y	Deng et al, 2015a
	WIN	Rat	+	+		Y		Pascual et al, 2005
	THC	Mouse	+		+			Deng et al, 2015b
CB2	AM1241	Rat	+			N	Y	Rahn et al, 2008
	AM1710	Mouse, rat	+		+	N	Y	Deng et al, 2012, 2015b
	AM1714	Rat	+			N	Y	Rahn et al, 2008
DAGLβ	KT-109	Mouse	+					Wilkerson et al, 2016a
PPARα	PEA	Mouse	+			N	N	Donvito et al, 2016
Vincristine-induced peripheral neuropathy
CB1 & CB2	WIN	Rat	+			Y	Y	Rahn et al, 2007
CB2	AM1241	Rat	+			N	Y	Rahn et al, 2007
Diabetic (streptozotocin-induced) peripheral neuropathy
CB1 and CB2	THC	Mouse, rat		+				Williams et al, 2008
	WIN	Mouse, rat	+	+		Y/N	Y	Bujalska, 2008; Doğrul et al, 2004; Ikeda et al, 2013; Jahanabadi et al, 2016; Mohammadi-Farani et al, 2010; Ulugol et al, 2004; Vera et al, 2012; Vincenzi et al, 2013
CB2	AM1241	Rat	+					Bujalska-Zadrożny et al, 2015; Bujalska, 2008
	JWH-015	Mouse	+	+	+		Y	Castany et al, 2016
FAAH	URB597	Rat	+	+				Hasanein et al, 2009
	URB937	Rat	+					Sasso et al, 2015
MAGL	MJN110	Rat	+					Niphakis et al, 2013
PPARα	PEA	Mouse	+			Y	Y	(Donvito et al, 2015)
Nitroglycerin-induced migraine and hyperalgesia
FAAH	PF-3845	Mouse	+			Y		(Nozaki et al, 2015)
	URB597	Mouse	+			Y		Nozaki et al, 2015
	URB937	Rat		+				Greco et al, 2015

Positive analgesic results for mechanical, thermal, and cold stimuli are denoted with a ‘+’. In general, the mechanical stimuli refer to von Frey filament, pressure (Randal Stiletto) or similar testing. Thermal stimuli generally included focused beams of light, hotplate plantar withdrawal or tail flick, depending on the type of neuropathy. Cold stimuli referred to positive results using plantar acetone, cold plate or similar testing. Cannabinoid (CB₁ or CB₂) receptors involvement includes results from mice lacking the gene of interest or experiments using pharmacologic antagonists. Full or partial blockade of analgesic effects is denoted with a ‘Y’ (yes). Negative results are reported with an ‘N’ (no). Conflicting results between experiments are denoted ‘Y/N’ (yes/no). See listed references for more details. Anandamide; AEA. Delta-9-tetrahydrocannabinol; THC. Palmitoylethanolamide; PEA. WIN55,212.; WIN.