Fig. 1.

Effect of protein kinase inhibitors on melanoma cell proliferation (a). The effect of combination of protein kinase inhibitors on melanoma cells proliferation (b). The proliferation of cells was assessed with the BrdU ELISA test after 48 h and 72 h. Values are expressed as mean ± standard deviation in 8 wells in three independent experiments. All results are presented as experimental mean values which were compared using one-way ANOVA with the Tukey’s post hoc test (Statistica ver. 12, StatSoft); asterisk (*) indicates a significant difference: *p < 0.05, **p < 0.005, ***p < 0.0005