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. 2017 Nov 27;14(12):1009–1010. doi: 10.1038/cmi.2017.111

Figure 1.

Figure 1

Characteristics of replicative senescent T cells. Replicative senescent T cells lose the expression of CD28 and acquire the expression of CD57, NK cell-related receptors, and chemokine receptors for peripheral homing. They have high levels of perforin and granzymes, and produce high amounts of IFN-γ and TNF upon TCR stimulation. However, these cells are less proliferative to TCR or IL-7 stimulation compared to young T cells. They exhibit constitutive p38 mitogen-activated protein kinase (MAPK) activation, leading to inhibition of autophagy, proliferation, and telomerase activity. TCR; T cell receptor, TNF; tumor necrosis factor.