Table 2. Interpretation and clinical significance of hepatitis B serologies.

HBsAg	Anti-HBc	Anti-HBs	IgM anti-HBc	Interpretation
Negative	Negative	Negative		Susceptible
Negative	Negative	Positive, >10 mIU/mL		Immune due to vaccination
Negative	Positive	Positive		Immune due to natural infection
Positive	Negative	Negative	Negative	Early acute infection
Positive	Positive	Negative	Positive	Acutely infection
Positive	Positive	Negative	Negative	Chronic infection
Negative	Positive	Negative		Either: Recovering from acute HBV infection Distantly immune: test not sensitive enough to detect a very low level of anti-HBs in serum Susceptible with a false positive anti-HBc Chronically infected with undetectable level of HBsAg present in serum