Fig. 5.

CRO treatment preserves normal short-term renal function. (A) Gomori trichrome staining of renal cortex illustrates healthy kidney histology, at 28 days post-treatment, in mock-infected mice treated with CRO (representative image from n=10 mice). (B) UPEC-infected mice that resolved pyelonephritis via CRO treatment and lacked gross scars demonstrated minor glomerular sclerosis, but displayed otherwise normal kidney architecture (representative image from n=14 mice). Scale bar for A and B: 50 µm. (C) Blood urea nitrogen (BUN) rose over a 30-day interval in UPEC-infected mice (n=4-5 per condition) that did not receive antibiotics (*P=0.029 by Mann–Whitney U-test, 5 days versus 30 days), but remained at baseline in mice that were treated with CRO (P= not significant by Mann–Whitney U-test, 5 days versus 30 days).