Fig. 6.

Successful CRO treatment preserves long-term renal function in most UPEC-infected mice. Mock-infected mice (PBS; circles) and UPEC-infected mice (triangles) were treated with CRO for 5 days beginning at 5 dpi and aged to 30 weeks (two to three experiments with total n=10-15 per condition). Serum was analyzed for creatinine (SCr; A) and blood urea nitrogen (BUN; B), and urine protein was measured (UPro; C). Most UPEC-infected mice demonstrated normal serum creatinine, BUN and urine protein at 30 weeks of age (P= not significant by Mann–Whitney U-test for each analyte), although one UPEC-infected mouse that displayed notable bilateral scars also had marked elevation in these biochemical markers.