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Reduction of complex I, II and IV activities in isolated mitochondria from the cerebellum of asymptomatic KIKO mice. Mitochondria were isolated from the cerebellum of P90 mice. Activities of several mitochondrial respiratory chain complexes in the cerebellum of KIKO and control mice were measured. All activity values were normalized to citrate synthase and expressed as percentages of those of control mice (n=3 mice per group; *P<0.05, **P<0.01, two-tailed, unpaired Student's t-test).
