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. 2017 Dec 7;7:17167. doi: 10.1038/s41598-017-17460-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of DNA methylation. (a) Statistics on the numbers of mCs. (b) The distribution of mCs in CK, LE and HE. (c) The statistics of DMRs. (d) The mean DNA methylation level of in the different gene regions. (e) The box-plot of DNA methylation level in the different gene region. 1: CG methylation in gene upstream; 2: CHG methylation in gene upstream; 3: CHH methylation in gene upstream; 4: CG methylation in gene downstream; 5: CHG methylation in gene downstream; 6: CHH methylation in gene downstream; 7: CG methylation in gene body; 8: CHG methylation in gene body; 9: CHH methylation in gene body.