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. 2017 Dec 7;7:17159. doi: 10.1038/s41598-017-17144-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alanine scanning mutagenesis of the extracellular domain of C99 reveals sequence specific increases and decreases in Aβ production. Comparison of the levels of Aβ38, Aβ40 and Aβ42 produced by γ-secretase cleavage of wild- type β-CTF and the corresponding N terminal alanine mutants. Values are the means ± S.E., n > 5; *p < 0.05; **p < 0.01; ***p < 0.001, compared with control.