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. 2017 Dec 7;7:17156. doi: 10.1038/s41598-017-16009-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cdx2 directly competes with Oct4 on genome-wide regulation of lineage segregation (See also Figs S2 and S3). (a) Relationship between gene expression difference of TS/ES and Cdx2-ChIP-Seq association score. X-axis shows the gene rank after sorting the genome according to expression fold change between TS and ES cells. Y-axis shows the average Cdx2 binding association score from a sliding window of 500 genes. (b) Relationship between gene expression difference of TS/ES and Oct4-ChIP-Seq association score. X-axis shows the gene rank after sorting the genome according to expression fold change between TS and ES cells (Kidder and Palmer, 2010). Y-axis shows the average Oct4 binding association score from a sliding window of 500 genes. (c) Cdx2 ChIP-Seq peaks, H3K27me3 Peaks, DNase Peaks from TS cells in the Pou5f1 gene region viewed with IGV; OSN ChIP-Seq peaks, H3K27me3 Peaks, DNase Peaks from ES cells in the Cdx2 gene region viewed with IGV. OSN: Oct4-Sox2-Nanog. (d) Venn diagram show silencer candidates in TS cell (left); Venn diagram show silencer candidates in ES cell (right). (e) GO analysis of silencer-related genes in TS cells; GO analysis of silencer-related genes in ES cells.