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. 2017 Dec 7;7:17175. doi: 10.1038/s41598-017-17384-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of mTORC1 signaling causes abnormalities in Achilles tendons. (A) Histology of Achilles tendons from wild-type (WT) (a-d) and Scx-Cre; Raptor ^f/f littermates (e–h) at postnatal day 30 (P30). Low magnification (5X) image of Hematoxylin and Eosin (H&E) staining of Achilles tendon (a and e). High magnification image (40X) of H&E (b and f), toluidine blue (c and g), and BrdU (d and h) staining of the mid-substance of Achilles tendons. Scale bars in a and e indicate 200 μm, and all other scale bars indicate 50 μm. (B) Quantification of cell density and total cell number using H&E-stained sections of Achilles tendons (n = 3, *p < 0.05). (C) H&E staining of the enthesis of the Achilles tendons from WT (a) and Scx-Cre; Raptor ^f/f littermates (c) at P30. Alcian blue staining of the enthesis of Achilles tendons from WT (b) and Scx-Cre; Raptor ^f/f littermates (d) at P30. Yellow arrows indicate representative fibrocartilage cells. Scale bars indicate 100 μm.