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. 2017 Dec 7;7:17175. doi: 10.1038/s41598-017-17384-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gain of mTORC1 signaling induces tendon abnormalities. (A) Hematoxylin and Eosin (H&E) staining of patellar tendons from wild-type (WT) (a) and Scx-Cre; Tsc1 ^f/f littermates (b) at P30. Scale bars indicate 200 μm. (B) H&E and toluidine blue-stained sections of patellar tendons from WT (a–c) and Scx-Cre; Tsc1 ^f/f littermates (d–f) at P4 and P30. Scale bars indicate 50 μm. Arrows indicate vascularization in the midsubstance (blue arrows), as well as in regions between the patellar tendon and surrounding fat pads (yellow arrows) (C) Quantification of cell density and total cell number using toluidine blue-stained sections of patellar tendons (n = 3, *p < 0.05). (D) BrdU staining of patellar tendons from WT and Scx-Cre; Tsc1 ^f/f littermates at P30. Scale bars indicate 50 μm.