Table 1.

Pharmacokinetic parameters of metapristone in rats.

Parameters	p.o.22.5 mg/kg		p.o. 45 mg/kg		p.o. 90 mg/kg		i.v. 10 mg/kg
	Male	Female	Male	Female	Male	Female	Male	Female
C max (mg/L)	0.03 ± 0.01	0.27 ± 0.05*	0.14 ± 0.10	0.65 ± 0.22*	0.55 ± 0.18	0.79 ± 0.20*	4.05 ± 0.25	6.05 ± 0.67*
T max (h)	5.7 ± 2.0	9.0 ± 7.5	7.7 ± 2.9	11.0 ± 12.3	10.3 ± 2.7	7.58 ± 3.38	—	—
t 1/2 (h)	8.0 ± 2.4	10.81 ± 3.2	8.11 ± 4.31	10.71 ± 3.71	4.62 ± 3.00	8.83 ± 7.30	9.45 ± 4.993	5.18 ± 3.41
MRT (0-t) (h)	11.2 ± 2.12	14.42 ± 5.65	13.91 ± 1.17	13.73 ± 6.91	12.75 ± 2.43	15.62 ± 5.82	1.56 ± 0.41	1.68 ± 0.72
AUC (0-t) (mg/L*h)	3.57 ± 1.09	4.05 ± 1.62*	1.96 ± 1.32	9.63 ± 4.54*	8.76 ± 0.07	14.86 ± 2.19*	5.52 ± 1.15	9.75 ± 2.32*
AUC (0-∞) (mg/L*h)	4.47 ± 1.11	4.23 ± 1.64	2.04 ± 1.33	11.31 ± 3.17*	8.92 ± 0.96	15.56 ± 2.10*	5.46 ± 1.15	9.81 ± 2.34*
V d /F (L/kg)	803.5 ± 266.9	77.32 ± 36.0*	768.0 ± 126.6	67.63 ± 47.6*	92.5 ± 91.7	86.33 ± 62.9*	24.34 ± 5.52	8.02 ± 6.13*
CL/F (L/h/kg)	69.61 ± 14.29	7.03 ± 5.50**	46.93 ± 20.7	5.25 ± 0.96**	11.74 ± 3.02	4.85 ± 1.76*	1.98 ± 0.39	1.06 ± 0.25*
F (%)	28.7	18.46	7.90	22.02	17.63	16.87	—	—

*P < 0.05, **P < 0.01, compared with those of males.