Table 2.

Pharmacokinetic parameters of oral metapristone in beagle dogs.

Parameters	p.o. 5.6 mg/kg		p.o. 11.25 mg/kg		p.o. 22.5 mg/kg
	Male	Female	Male	Female	Male	Female
C max (mg/L)	0.05 ± 0.00	0.07 ± 0.01*	0.15 ± 0.03	0.19 ± 0.03*	0.30 ± 0.02	0.38 ± 0.01*
T max (h)	2.00 ± 0.00	1.67 ± 0.57	2.00 ± 0.00	1.67 ± 0.57	2.00 ± 0.00	1.66 ± 0.57
t 1/2 (h)	8.18 ± 2.90	8.05 ± 1.12	5.54 ± 2.30	8.57 ± 1.12	6.79 ± 2.81	7.19 ± 2.83
MRT (0-t) (h)	7.16 ± 1.12	7.23 ± 1.69	5.68 ± 1.10	8.62 ± 0.56	6.18 ± 0.34	7.00 ± 0.61
AUC (0-t) (mg/L*h)	0.21 ± 0.03	0.56 ± 0.11*	0.75 ± 0.10	1.28 ± 0.10*	1.56 ± 0.31	2.40 ± 0.15*
AUC (0-∞) (mg/L*h)	0.23 ± 0.05	0.58 ± 0.12*	0.77 ± 0.11	1.33 ± 0.11*	1.60 ± 0.34	2.56 ± 0.21*
V d/F (L/kg)	187.10 ± 8.21	125.60 ± 7.10*	136.30 ± 13.08	104.80 ± 9.17*	123.10 ± 15.00	89.23 ± 14.10*
CL /F (L/h/kg)	15.93 ± 1.60	9.92 ± 0.38*	14.48 ± 1.30	8.48 ± 0.18*	12.59 ± 2.19	8.83 ± 0.76*

*P < 0.05, compared with those of males.