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. 2017 Dec 7;7:17134. doi: 10.1038/s41598-017-17373-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Chronic administration of canola oil-rich diet modulates behavioral responses of 3xTg mice. Six-month old 3xTg mice were randomized to receive regular chow diet (CTR) or diet enriched with canola oil (CO) until they were 12-month-old. (A) Mice were tested in the Y-maze paradigm for the number of entries, and the percentage of alternation. (B) Percentage of freezing in the contextual and cued phases of the fear conditioning paradigm. (C) Mice were also assessed in the Morris water maze paradigm for the number of entries to the platform zone, and the time spent in the platform zone. (CTR n = 11, CO, n = 10) (*p < 0.05).