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. 2017 Dec 7;7:17134. doi: 10.1038/s41598-017-17373-3

Figure 2.

Figure 2

Effect of chronic administration of canola oil-rich diet on brain Aβ levels and deposition. (A) RIPA-soluble (RIPA) and formic acid extractable (F.A.) Aβ 1-40 and Aβ 1-42 levels in brain cortex homogenates of 3xTg receiving vehicle (CTR) (n = 5) or canola oil (CO) (n = 5). (B) Ratios of Aβ 42/40 for RIPA soluble and formic acid soluble fraction measured in brain from 3xTg controls (CTR) or 3xTg treated with canola oil-rich diet (CO). (C) Quantification of the area occupied by Aβ immunoreactivity in brains of 3xTg mice receiving vehicle (CTR) (n = 3) or canola oil (CO) (n = 3). (D) Representative Western blots of APP, BACE1, ADAM10, APH1, Nicastrin, Pen2, PS1, ApoE, IDE and CD10 in the brain cortex homogenates from 3xTg mice receiving vehicle (CTR) (n = 4) or canola oil (CO) (n = 4). (E) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel.