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. 2017 Dec 7;7:17134. doi: 10.1038/s41598-017-17373-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of chronic administration of canola oil-rich diet on synaptic integrity and neuroinflammation. (A) Representative western blot analyses of synaptophysin (SYP) and post-synaptic density protein 95 (PSD95) in brain cortex homogenates of 3xTg mice treated with vehicle (CTR) or canola oil (CO). (B) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (CTR, n = 4; CO, n = 4) (*p < 0.05). (C) Representative images of brain sections from 3xTg mice receiving canola oil (CO) vehicle (CTR) immunostained with PSD95 antibody. (D) Representative western blot analyses of GFAP and IBA1 in brain cortex homogenates of 3xTg mice treated with vehicle (CTR) or canola oil (CO). (E) Densitometric analyses of the immunoreactivities to the antibodies shown in the previous panel (CTR, n = 4; CO, n = 4).