Table 2.
Antifungal susceptibility of 149 isolates and categorical agreement between CLSI 2008 and 2012
| Species/ antifungal (n) | MIC range (mg/L) |
MIC 50
(mg/L) |
MIC 90
(mg/L) |
CLSI 2008 n (%) |
CLSI 2012 n (%) |
||||
|---|---|---|---|---|---|---|---|---|---|
| S | I | R | S | SDDa/I | R | ||||
| C. albicans (60) | |||||||||
| Fluconazole | ≤ 1–8 | 1 | 1 | 60 (100) | – | – | 56 (93.3) | 2 (3.3) | 2 (3.3) |
| Voriconazole | ≤ 0.12 | 0.12 | 0.12 | 60 (100) | – | – | 60 (100) | – | – |
| Caspofungin | ≤ 0.25–1 | 0.25 | 0.25 | 60 (100) | – | – | 56 (93.3) | 1 (1.6) | 3 (5) |
| Micafungin | ≤ 0.06–1 | 0.06 | 0.06 | 60 (100) | – | – | 58 (96.6) | 1 (1.6) | 1 (1.6) |
| C. tropicalis (34) | |||||||||
| Fluconazole | ≤ 1–8 | 1 | 1 | 34 (100) | – | – | 32 (94.1) | 1 (2.9) | 1 (2.9) |
| Voriconazole | ≤ 0.12 | 0.12 | 0.12 | 34 (100) | – | – | 34 (100) | – | – |
| Caspofungin | ≤ 0.25–1 | 0.25 | 0.25 | 34 (100) | – | – | 34 (100) | – | – |
| Micafungin | ≤ 0.06–0.5 | 0.06 | 0.06 | 34 (100) | – | – | 34 (100) | – | – |
| C. glabrata (30) | |||||||||
| Fluconazole | ≤ 1–64 | 4 | 8 | 28 (93.3) | – | 2 (6.6) | 0 | 28 (93.3) | 2 (6.6) |
| Caspofungin | < 0.25–1 | 0.25 | 0.25 | 30 (100) | – | – | 29 (96.6) | – | 1 (3.3) |
| Micafungin | < 0.06–0.5 | 0.06 | 0.06 | 30 (100) | – | – | 29 (96.6) | – | 1 (3.3) |
| C. parapsilosis (15) | |||||||||
| Fluconazole | ≤ 1–8 | 1 | 8 | 15 (100) | – | – | 13 (86.6) | 1 (6.6) | 1 (6.6) |
| Voriconazole | ≤ 0.12–0.25 | 0.12 | 0.12 | 15 (100) | – | – | 15 (100) | – | – |
| Caspofungin | < 0.25–1 | 1 | 1 | 15 (100) | 15 (100) | – | – | ||
| Micafungin | < 0.06–1 | 0.5 | 1 | 15 (100) | 15 (100) | – | – | ||
| C. guilliermondi (3) | |||||||||
| Fluconazole | 2–8 | 2 | 8 | 3 (100) | – | – | – | ||
| Voriconazole | < 0.12 | < 0.12 | < 0.12 | 3 (100) | – | – | – | ||
| Caspofungin | 0.25–1 | 0.25 | 1 | 3 (100) | – | – | – | ||
| Micafungin | 0.5 | 0.5 | 0.5 | 3 (100) | – | – | – | ||
| C. kruzei (2) | |||||||||
| Voriconazole | ≤ 0.12 | 0.12 | 0.12 | 2 (100) | 2 (100) | – | – | ||
| Caspofungin | ≤ 0.25–0.5 | 0.25 | 0.5 | 2 (100) | 1 | 1 | – | ||
| Micafungin | 0.12 | 0.12 | 0.12 | 2 (100) | 2 | – | – | ||
| Otherb (5) | |||||||||
| Fluconazole | ≤ 1–16 | 2 | 16 | 3 (60) | 2 (40) | – | – | – | |
| Voriconazole | ≤ 0.12 | 0.12 | 0.12 | 5 (100) | – | – | – | – | – |
| Caspofungin | ≤ 0.25- > 4 | 0.25 | 4 | 4 (80) | – | – | – | – | – |
| Micafungin | < 0.06- > 4 | 0.12 | 4 | 4 (80) | – | – | – | – | – |
MIC minimal inhibitory concentration, S susceptible, I intermediate, R resistant, SDD susceptible dose dependent, CLSI Clinical Laboratory Standards Institute
aSDD applies for fluconazole and voriconazole instead of intermediate
bOther species: C. lusitaniae, C. pelliculosa, C. norvegensis, C. lypolitica, C. inconspicua