Table 3.
Pulmonary function, FeNO and symptoms in asthma patients with and without obesity (n = 472)
| BMI < 30 kg/m2 n = 224 | BMI ≥ 30 kg/m2 n = 248 | Unadjusted difference (95% CI)a | Adjusted difference (95% CI)a | |
|---|---|---|---|---|
| Lung function | ||||
| FEV1, % pred, mean (SD) | 99.9 (18.1) | 97.0 (17.1) | −2.9 (−6.1, 0.3) | −3.2 (−6.3, −0.03) |
| FVC, % pred, mean (SD) | 111.8 (17.9) | 107.4 (15.5) | −4.4 (−7.4, −1.4) | −4.9 (−7.8, −2.0) |
| FEV1/FVC, mean (SD) | 74.0 (8.1) | 74.9 (8.0) | 0.9 (−0.5, 2.4) | 0.5 (−0.9, 1.9) |
| FeNO, ppb, mean (SD) | 21.9 (16.9) | 19.2 (13.9) | −2.7 (−5.5, 0.1) | −1.8 (−4.6, 1.0) |
| Symptoms | ||||
| Dyspnea, n (%) | 78 (35) | 114 (46) | 11.1 (2.3, 20.0) | 9.5 (0.8, 18.2) |
| Wheezing, n (%) | 39 (17) | 88 (36) | 18.1 (10.3, 25.9) | 18.5 (10.8, 26.2) |
| Coughing with mucus, n (%) | 49 (22) | 56 (23) | 0.7 (−6.8, 8.3) | 0.9 (−6.5, 8.4) |
| Coughing without mucus, n (%) | 72 (32) | 78 (32) | −0.7 (−9.1, 7.8) | −2.0 (−10.4, 6.3) |
| Symptoms worsen during: | ||||
| Physical activity, n (%) | 77 (34) | 121 (49) | 14.8 (6.0, 23.7) | 12.9 (4.2, 21.6) |
| Dust/pollen/animal exposure, n (%) | 79 (35) | 75 (30) | −5.0 (−13.5, 3.5) | −3.5 (−11.6, 4.5) |
| Foggy weather, n (%) | 78 (35) | 94 (38) | 3.1 (−5.6, 11.8) | 1.7 (−6.6, 9.9) |
| Night, n (%) | 26 (12) | 38 (15) | 3.7 (−2.5, 9.9) | 3.0 (−3.3, 9.3) |
| Getting up in the morning, n (%) | 33 (15) | 17 (7) | −7.9 (−13.5, −2.2) | −8.1 (−14.0, −2.2) |
| ICS prescription, n (%) | 107 (48) | 123 (50) | 1.8 (−7.2, 10.9) | 2.5 (−6.7, 11.7) |
BMI body mass index, CI confidence interval, FEV 1 forced expiratory volume in one second, FVC forced vital capacity, Fe NO fractional exhaled nitric oxide, ppb parts per billion, ICS inhalation corticosteroids
aDifferences are presented as difference in means for continuous variables and difference in percentage for categorical variables
Analyses are adjusted for age, sex, smoking, education levels, ethnicity, physical activity, alcohol use, and prescription of ICS