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. 2017 Dec 7;17:832. doi: 10.1186/s12885-017-3827-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The PKCα - FOXC2 - p120-catenin pathway is prognostically relevant in breast cancer patients. a High expression of FOXC2 and low expression of CTNND1 (p120-catenin) in ER⁻ patients correlate with poorer relapse free survival (RFS). b TNBC/Basal-like patients express higher levels of PRKCA (PKCα), FOXC2, and lower levels of CTNND1 compared to patients of other molecular subtypes. Molecular subtypes were determined by PAM50 assay. Gene expression data were computed and analyzed on UCSC Genome Browser (http://genome.ucsc.edu/). c High expression of FOXC2 and low expression of CTNND1 in ER⁺ patients are associated with a tendency towards poorer RFS. Survival data and significance were analyzed and obtained from PROGgene as previously described [55]