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. 2017 Dec 6;16:177. doi: 10.1186/s12943-017-0745-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — CR-PDX cell lines are amenable to in vitro preclinical applications. a CR-PDX cells were removed from CR conditions and treated with the indicated inhibitors (n = 3, mean ± SD shown). In vitro drug sensitivity of CR-PDX cells was compared to in vivo response of the parental tumor. Means ± error are shown for each model. N = 8 (OV0857F), n = 8 (HLXF-036LN), n = 9 (LG0567F), and n = 10 (HLXF-056) (b) CR-PDX cells are amenable to gene knockdown studies using siRNA. CR-HLXF-036LN cells were reverse transfected with indicated siRNAs for 72 h. Knockdown efficiency was confirmed by qPCR and the effect of knockdown on viability was assessed at the end of study, (N = 3, mean ± SD shown, ***p < 0.05, Student’s t-test, two-tailed)