Fig. 1.

HDAC inhibitor VPA modulates TP and TS protein expression in CRC cell lines. TP, AcH3, TS (a) and p53 (a and b) basal protein expression was determined by western blot on the indicated CRC cells. c TP, TS, p53 and AcH3 protein expression was determined by western blot on HCT116, HCT116 p53^−/−, HT29 and SW620 cells untreated or treated for 24 h with increased doses of VPA. GAPDH or γ-tubulin were used as protein loading control